Life After Star*D: Lessons Learned and the Next Steps for Managing Depression

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Life After Star*D: Lessons Learned and the Next Steps for Managing Depression ~ Member Rate - $25.00

Life After Star*D: Lessons Learned and the Next Steps for Managing Depression ~ Non-Member Rate - $30.00

Session Summary

Major depression is a complex disorder, with as many as 50% of patients non-responsive to initial antidepressant therapy. The NIMH sponsored Sequenced Treatment Alternatives to Relieve Depression (STAR*D) set out to determine what the next “best step” was for patients not responding adequately to one or more prior treatments. In addition, given the large, representative patient sample and comprehensive data collected, STAR*D was able to provide clinical and genetic predictors of treatment outcomes.

This session will provide an in-depth discussion on the lessons learned from STAR*D, and provide a discussion on why Practical Clinical Trials involving “real world” patients, such as STAR*D, are more likely to provide results that can be immediately utilized in clinical practice. Important outcomes from secondary clinical and genetic studies will also be reviewed. Lastly, the potential role of personalizing treatments for MDD and future treatment directions will be discussed.

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Faculty Information

Ben Kurian, MD, MPH

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Ben Kurian, MD, MPH
Assistant Professor of Psychiatry
UT Southwestern Medical Center
Dallas, TX

Dr. Kurian is an Assistant Professor in the Department of Psychiatry at UT Southwestern Medical Center (UTSW). He completed his postdoctoral research fellowship, which was mentored by Dr. Madhukar Trivedi, in the Mood Disorders Clinical Intervention Program in 2008 at UTSW. He is a board-certified psychiatrist that completed his psychiatry residency at Vanderbilt University Medical Center.

While at Vanderbilt, Dr. Kurian also has completed a Masters in Public Health (MPH), providing him with essential training and knowledge in research design and methodologies. Dr. Kurian worked closely with large epidemiologic databases to discover the effects of the FDA’s black box warning on the prescription rates of antidepressant medications.

During his research fellowship at UTSW he expanded his skills in diagnostic interviewing and has received training and certification on a number of objective research tasks. He has also presented poster abstracts at the following distinguished annual meetings: the American Psychiatric Association (APA), the NIMH New Clinical Drug Evaluation Unit (NCDEU), and the American College of Neuropsychopharmacology (ACNP). Dr. Kurian has been bestowed a number of travel awards to attend meetings to further his career development, including: the Career Development Institute (CDI) for Psychiatry, the American Society for Clinical Psychopharmacology (ASCP), APIRE (APA) Junior Investigators Research Colloquium, and the NCDEU New Investigator’s Meeting.In addition, he was recently awarded the NIH Loan Repayment Program.

Since joining the faculty at UTSW, Dr. Kurian has been involved as a co-investigator, and more recently as a principal investigator on a number of randomized controlled trials. Specifically, he served as a co investigator on the large multicenter Combining Medications to Enhance Depression Outcomes (CO−MED) trial. He currently serves as the UTSW site PI for the multicenter NIMH funded collaborative Recovery After Initial Schizophrenia Episode (RAISE) study. Additionally, Dr. Kurian served as the safety officer for two large, multicenter trials and has worked closely with leading experts in the clinical trial design and implementation of depressive disorders.

Grant/Research Support:

Targacept, Inc., National Institute of Mental Health, aGency for Healthcare Research and Quality

Learning Objectives

Identify the gap between efficacy trials and “real world” patients and the implications for clinical practice.
Review the lessons learned from STAR*D, and how they translate to clinical practice.
Discuss how clinical trials influence clinical practice.
Discuss the future direction of depression comparative effectiveness trials.

Continuing Education Credit

Activity Dates: 04/19/2010 - 04/19/2013
ACPE Contact Hours: 1.0
ACPE Number: 0284-0000-10-005-H01-P (Knowledge)
Nursing Credit Reminder: Note that ACPE and ACCME credit is accepted for certification renewal.

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ACPE The College of Psychiatric and Neurologic Pharmacists is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This self-study course provides 1.0 contact hours (0.10 CEUs) of knowledge-based continuing education credit from CPNP approved programming. The ACPE universal program number assigned to this course is 0284-0000-10-005-L01-P (1.0 contact hours).

ACPE approved contact hours are accepted for ANCC Certification Renewal (see pages 5 and 6): At least 50% (37.5 hours) of your 75 continuing education hours must be formally approved continuing education hours. Formally approved continuing education hours meet one or more of the criteria listed below:

Continuing nursing education (CNE) approved for nursing contact hours by an accredited provider or approver of nursing continuing education
Continuing medical education (CME) approved for CME hours
Sponsored by organizations, agencies, or educational institutions accredited or approved by the American Nurses Credentialing Center (ANCC) or the Accreditation Council for Continuing Medical Education (ACCME) or the Accreditation Council for Pharmacy Education (ACPE) or the Commission on Dietetic Registration

Course Requirements

This course is provided online at cpnp.org and consists of the speaker audio and slides. A PDF file of the slides is also provided and access is available to participants indefinitely although ACPE credit is available only through the course expiration date.

Participants in this course must complete an examination and achieve a score of 60% or greater. Successful completion of the course also requires the completion of a course evaluation. ACPE statements of credit can be retrieved by participants online at cpnp.org immediately upon successful completion of the course.

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Internet Explorer 6+, Firefox 2+ or Safari 3+
1024x768 resolution or greater
Adobe Flash Player 8+
512MB RAM
Any Operating System capable of the above requirements

Recommended:

Internet Explorer 7+, Firefox 3+ or Safari 3+
1280x768 resolution or greater
Adobe Flash Player 10+
Windows XP/2000/Vista and Mac OS 10.4 or better
512MB of RAM for Windows XP or Mac OS
1GB of RAM for Windows Vista

Target Audience

If you are a pharmacist, nurse practitioner or other healthcare professional involved in the medication therapy management of psychiatric and/or neurological patients, we invite you to participate in this online course.

Grant Support

This programming was supported in part by grants from Bristol-Myers Squibb, Otsuka America Pharmaceutical, Inc., Lilly USA, LLC, AstraZeneca and Cyberonics.