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McKeon A, Robinson MT, McEvoy KM, et al. Stiff-man syndrome and variants: clinical course, treatments, and outcomes. Archives of Neurology. 2012;69(2):230-8. doi:10.1001/archneurol.2011.991.
BACKGROUND: Little information is available about the incidence of stiff-man syndrome (SMS) (the classic form or its variants) or about long-term treatment responses and outcomes. OBJECTIVE: To comprehensively describe the characteristics of a cohort of patients with SMS. DESIGN: Observational study. SETTING: Mayo Clinic, Rochester, Minnesota. PATIENTS: Ninety-nine patients with classic SMS vs variants of the disorder, both glutamic acid decarboxylase 65 kD isoform (GAD65) antibody seropositive and...
Kleiter I, Hellwig K, Berthele A, et al. Failure of natalizumab to prevent relapses in neuromyelitis optica. Archives of Neurology. 2012;69(2):239-45. doi:10.1001/archneurol.2011.216.
OBJECTIVE: To describe first experiences with the integrin inhibitor natalizumab, given to patients with suspected relapsing-remitting multiple sclerosis (MS) who were later diagnosed with aquaporin 4-positive neuromyelitis optica (NMO). DESIGN: Retrospective case series. SETTING: Neurology departments at tertiary referral centers in Germany. PATIENTS: Patients with NMO who tested positive for antibodies to aquaporin 4. INTERVENTION: Treatment with natalizumab. MAIN OUTCOME MEASURES: Relapses and...
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