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Ni P, Ma X, Lin Y, et al. Methionine sulfoxide reductase A (MsrA) associated with bipolar I disorder and executive functions in A Han Chinese population. j Affect Disord 2015;184:235-238. doi:10.1016/j.jad.2015.06.004.
BACKGROUND: The oxidative stress hypothesis proposed to explain bipolar I disorder (BD I) pathogenesis has gained growing attention based on its association with cognitive impairment. The aim of the present study was to explore the association of the methionine sulfoxide reductase A (MsrA) gene with BD I as well as executive functions of BD I patients. METHODS: A total of 44 tagging single-nucleotide polymorphisms within the MsrA gene were selected to analyze gene association with BD I in 375 BD I...
Lisiecka DM, O'Hanlon E, Fagan AJ, et al. BDNF Val66Met polymorphism in patterns of neural activation in individuals with MDD and healthy controls. j Affect Disord 2015;184:239-244. doi:10.1016/j.jad.2015.06.002.
BACKGROUND: Rs6265 single nucleotide polymorphism, which influences brain-derived neurotrophic factor (BDNF) levels in the cortical and subcortical brain structures, may result in distinguished patterns of neural activation during a major depressive disorder (MDD) episode. Valine homozygotes with high levels of BDNF and methionine carriers with lower levels of BDNF may present specific neural correlates of MDD. In our study we have tested differences in blood oxygen level dependant (BOLD) signal between...
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