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Abou-Khalil B, Wheless J, Rogin J, et al. A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures. Epilepsia. 2013;54(11):1968-76. doi:10.1111/epi.12373.
PURPOSE: A diazepam auto-injector (AI) has been developed for intramuscular administration to treat acute repetitive seizures (ARS). The objective of this study was to evaluate the efficacy and safety of the diazepam AI when administered by caregivers to control an episode of ARS. METHODS: In this phase III, randomized, double-blind, parallel-group, placebo-controlled, multicenter study, subjects with epilepsy on a stable antiepileptic drug regimen who required intermittent medical intervention to control...
Badawy RAB, Vogrin SJ, Lai A, Cook MJ. The cortical excitability profile of temporal lobe epilepsy. Epilepsia. 2013;54(11):1942-9. doi:10.1111/epi.12374.
PURPOSE: Transcranial magnetic stimulation (TMS) was used to characterize measurable changes of cortical excitability in patients who were undergoing medical and surgical management of temporal lobe epilepsy (TLE) to investigate whether these alterations depended on timing of achieving seizure control throughout the course of illness and method of management. METHODS: Eighty-five patients with TLE divided into (1) drug naive-new onset, (2) early medically refractor, and (3) late medically refractory, (4)...
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