Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder
Source: Journal of Affective Disorders
Publication year: 2011Source: Journal of Affective Disorders, In Press, Corrected Proof, Available online 7 September 2011Elizabeth, Hare , Javier, Contreras , Henriette, Raventos , Deborah, Flores , Alvaro, Jerez , ... Background: Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. In this study, the heritabilities of BPD and the Big Five personality factors and the genetic correlations between BPD and personality factors are reported. Methods: The participants in this study were 1073 individuals from 172 families of Mexican or Central American ancestry. Heritabilities and genetic correlations were calculated under a polygenic model using the maximum-likelihood method of obtaining variance components implemented in the SOLAR software package. Results: Heritabilities of 0.49, 0.43, and 0.43 were found for the narrowest phenotype (schizoaffective bipolar and bipolar I),...