[Correspondence] Exon-skipping therapy for Duchenne muscular dystrophy
Source: The Lancet
Sebahattin Cirak and colleagues (Aug 13, p 595) report impressive results with systemic exon-skipping therapy for patients with Duchenne muscular dystrophy. However, reliance on immunohistochemistry and western blots alone could be very misleading. Of other factors, non-specific, false-positive signals from muscle membrane and inaccurate immunoblot quantitation because of biopsy sample variations are difficult to eliminate.