abuse
The role of adverse events and related safety data in the pre-market evaluation of drug abuse potential
Publication year: 2010Source: Drug and Alcohol Dependence, In Press, Corrected Proof, Available online 2 September 2010Robert S., Mansbach , Kerri A., Schoedel , Jeffrey P., Kittrelle , Edward M., Sellers
Neuropsychological consequences of alcohol and drug abuse on different components of executive functions
Several studies have shown alterations in different components of executive functioning in users of different drugs, including cannabis, cocaine and heroin. However, it is difficult to establish a specific association between the use of each of these drugs and executive alterations, since most drug abusers are polysubstance abusers, and alcohol is a ubiquitous confounding factor.
Treatment of Alcohol Dependence Complicated by Depression and Anxiety Spectrum Disorders
Psychiatric disorders frequently co-occur with alcohol dependence. The National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) confirms previous epidemiologic data that bipolar disorder has the highest co-occurrence with alcoholism, followed by major depression, generalized anxiety disorder, and social anxiety. Although these disorders frequently co-occur, there are few studies evaluating the treatment of these comorbid conditions. The studies that are available typically focus on the treatment of the underlying psychiatric disorder.
mGluR2-Positive Allosteric Modulators: Therapeutic Potential for Treating Cocaine Abuse?
mGluR2-Positive Allosteric Modulators: Therapeutic Potential for Treating Cocaine Abuse?
Neuropsychopharmacology 35,
2007 (September 2010). doi:10.1038/npp.2010.93
Author: James E Barrett
Keywords:
Treatment for PTSD Related to Childhood Abuse: A Randomized Controlled Trial [Articles]
Objective
Posttraumatic stress disorder (PTSD) related to childhood abuse is associated with features of affect regulation and interpersonal disturbances that substantially contribute to impairment. Existing treatments do not address these problems or the difficulties they may pose in the exploration of trauma memories, an efficacious and frequently recommended approach to resolving PTSD.
In Response to “No Correlation Between Childhood Maltreatment and Telomere Length”
Glass et al (). have not replicated our preliminary finding of shorter telomeres in adults reporting a history of childhood maltreatment. Unfortunately, their analysis is not comparable with the design of our study, and the number of affected subjects in our preliminary study and in the analysis by Glass et al. is too small to draw robust conclusions regarding the effect of childhood maltreatment on telomere length.
A Single-Question Screening Test for Drug Use in Primary Care [Original Investigation]
Background Drug use (illicit drug use and nonmedical use of prescription drugs) is common but underrecognized in primary care settings. We validated a single-question screening test for drug use and drug use disorders in primary care.