ADHD
Associations of MAOA-VNTR or 5HTT-LPR alleles with attention-deficit hyperactivity disorder symptoms are moderated by platelet monoamine oxidase B activity
The monoamine systems have been suggested to play a role in the biological basis of attention-deficit hyperactivity disorder (ADHD) symptoms. Thus, polymorphisms, for example, in the monoamine oxidase A (MAOA) and the serotonin transporter (5HTT) genes have been associated with ADHD-like phenotypes. Furthermore, platelet monoamine oxidase B (MAOB) activity has frequently been linked to impulsiveness-related traits. In this study, we have studied ADHD symptoms with regard to the combination of platelet MAOB activity and MAOA-variable number of tandem repeats (VNTR) or 5HTT-LPR genotype.
Maternal gestational diabetes and low socioeconomic status associated with increased risk of ADHD in offspring
Children exposed to maternal gestational diabetes mellitus and low socioeconomic status, particularly in combination, appear to be at an increased risk of developing childhood ADHD, according to a new report.
ADHD Medications and Risk of Serious Cardiovascular Events in Young and Middle-aged Adults [Original Contribution]
Context More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD). These agents can increase heart rate and blood pressure, raising concerns about their cardiovascular safety.
Objective To examine whether current use of medications prescribed primarily to treat ADHD is associated with increased risk of serious cardiovascular events in young and middle-aged adults.
ADHD Medications and Risk of Serious Cardiovascular Events in Young and Middle-aged Adults [Original Contribution]
Context More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD). These agents can increase heart rate and blood pressure, raising concerns about their cardiovascular safety.
Objective To examine whether current use of medications prescribed primarily to treat ADHD is associated with increased risk of serious cardiovascular events in young and middle-aged adults.
Dangerous New Treatment Guidelines for ADHD Unveiled
ADHD is often inaccurately diagnosed and prematurely treated with medication—especially under the pressure of heavy drug company marketing to physicians and direct advertising to parents and teachers.
New biochemical changes found in children with ADHD
A new study shows that children with ADHD have nearly 50 percent less of a protein that is important for attention and learning. The finding may mean that there are other biochemical disturbances in the brains of individuals with ADHD than was previously believed.
New ADHD gene study points to defects in brain signaling pathways
Pediatric researchers analyzing genetic influences in attention-deficit/hyperactivity disorder have found alterations in specific genes involved in important brain signaling pathways. The study raises the possibility that drugs acting on those pathways might offer a new treatment option for patients with ADHD who have those gene variants -- potentially, half a million US children.