Antipsychotics

2010-2011 Psychiatric Pharmacy Review Course - ACPE Credit Only

The Psychiatric Pharmacy Review Course (Review Course) is an excellent course of study and resource for those seeking a review of psychopharmacology and current standards of care. Read more about this session.

Increased Risk of Antipsychotic-Related QT Prolongation During Nighttime: A 24-Hour Holter Electrocardiogram Recording Study

Abstract: Most antipsychotic agents can cause QT prolongation, which causes torsades de pointes. The QT interval in healthy subjects is longer during nighttime than during daytime. The QT interval of patients treated with antipsychotics may be prolonged during nighttime, and the effects of antipsychotics on the QT interval may differ between antipsychotics. This study investigated the circadian dynamics of the QT interval in patients treated with antipsychotics and healthy controls, using a 24-hour Holter electrocardiogram in a clinical setting.

Does the Medication Pattern Reflect the CYP2D6 Genotype in Patients With Diagnoses Within the Schizophrenic Spectrum?

Background: Cytochrome P450 2D6 enzyme (CYP2D6) is an important metabolic pathway for many antipsychotics.

Recognizing Movement Disorders: Reviving Old Practices

Robin Hieber, Pharm.D., BCPP

Movement disorders have many different presentations and are defined as a group of syndromes that affect the ability for one to control movement in a given muscle or muscle group. Many of the medications we use to treat psychiatric illness (antipsychotics, lithium, and valproic acid) have the potential to cause movement disorders, often referred to as extrapyramidal side effects, though predictability is lacking. Antipsychotic-induced dopamine blockade can lead to acute dystonia, akathisia, and Parkinsonism, all of which are generally reversible if treatment is discontinued.

Wellbutrin and Antipsychotics

Would a combination of Wellbutrin and any antipsychotic be warranted in any cases?  Would this hypothetically just counteract and cancel each other out?   Christopher Ching, PharmD Inpatient Pharmacist Kaiser Permanente ...

Are Extrapyramidal Symptoms Less Recognized? Case Report of Modern Practitioners’ Unfamiliarity with First Generation Antipsychotics

Tara L. Purvis, PharmD, BCPP
Veteran Affairs Sierra Nevada Healthcare System
Reno, Nevada 89502

The author received no support of any kind in writing this manuscript and has no potential conflicts of interest to disclose.  

The case report was published in Pharmacotherapy February 2011 and presented as a clinical pearl at the CPNP Annual Meeting. In that presentation however. emphasis was placed on the pharmacokinetics of fluphenazine decanoate.

A case is presented where initial suspicion of lithium toxicity was truly drug-induced Parkinsonism and tardive dyskinesia. The mistaken diagnosis underscores the need to improve training for movement disorder assessment.

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