Clozapine

Clozapine monitoring after discontinuation

We had this issue come up at our hospital this week, and we just wanted to hear others’ thoughts on the topic.  The package insert of clozapine states “When treatment with clozapine is discontinued (regardless of the reason), WBC ...

Clozapine Reverses Phencyclidine-Induced Desynchronization of Prefrontal Cortex through a 5-HT1A Receptor-Dependent Mechanism

Clozapine Reverses Phencyclidine-Induced Desynchronization of Prefrontal Cortex through a 5-HT1A Receptor-Dependent Mechanism

Neuropsychopharmacology 37,
723 (February 2012). doi:10.1038/npp.2011.249

Authors: Lucila Kargieman, Maurizio S Riga, Francesc Artigas
& Pau Celada

Keywords: dopamine; neurophysiology; second messengers; signal transduction; protein kinase C; ventral tegmental area; desensitization; D2 receptor; D5 receptor

your thoughts please

Hi all,   I am reviewing a non-formulary request for provigil and would love to have your input.    The psychiatrist is requesting it for sedation/fatigue secondary to clozapine.    Her ...

Drug-Induced Movement Disorders

Jack J. Chen, PharmD, FCCP, BCPS, CGP
Associate Professor
Loma Linda University
Loma Linda, CA

This comprehensive review covers approaches for both the recognition and management of drug-induced movement disorders. Pharmacotherapeutic approaches for treating akathisia, dystonia, Parkinsonism and tardive dyskinesia are explored. The importance of early detection via periodic assessment is discussed.

Significance of Clozapine Blood Levels

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Significance of Clozapine Blood Levels?

Hello- I got a question today from one of the Doctors at our hospital about a clozapine level he had drawn for a patient. I don't see anything about monitoring clozapine levels in any of our internet resources, so I thought I'd check if anyone had any ...

folic acid and clozapine

Hi list ! do any of you know of articles or rationale supporting the use of folic acid to prevent clozapinen induced neutropenia.  I have a patient with borderline neutropenia (N = 1.6)  who is tired of coming here to get blood work two ...

Comparative gene expression study of the chronic exposure to clozapine and haloperidol in rat frontal cortex

Publication year: 2011Source: Schizophrenia Research, Available online 10 December 2011S. Hossein Fatemi, Timothy D. Folsom, Teri J. Reutiman, Jessica Novak, Rachelanne H. Engel

Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test

Abstract
Rational  Negative symptoms of schizophrenia are insufficiently treated by current antipsychotics. However, research is limited by the
lack of validated models. Clinical data indicate that phencyclidine (PCP) abuse may induce symptoms resembling negative symptoms
in humans. Based on that, Noda et al.

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