Depression
2010-2011 Psychiatric Pharmacy Review Course - ACPE Credit Only
The Psychiatric Pharmacy Review Course (Review Course) is an excellent course of study and resource for those seeking a review of psychopharmacology and current standards of care. Read more about this session.
Genome-wide association study of comorbid depressive syndrome and alcohol dependence
Objective: Depression and alcohol dependence (AD) are common psychiatric disorders that often co-occur. Both disorders are genetically influenced, with heritability estimates in the range of 35–60%. In addition, evidence from twin studies suggests that AD and depression are genetically correlated.
Treatment With Duloxetine in Adults and the Incidence of Cardiovascular Events
Background: Cardiovascular events are inconclusively associated with duloxetine use in clinical trials and spontaneous reports. This analysis of cardiovascular events in relation to duloxetine use within a large health insurance database provides further data on the association.
Methods: This cohort study was conducted within a population with commercial health insurance.
The Effectiveness and Safety of Adjunctive Aripiprazole in Taiwanese Patients With Antidepressant-Refractory Major Depressive Disorder: A Prospective, Open-Label Trial
Abstract: There is currently no published clinical trial on the safety and effectiveness of aripiprazole in Taiwanese patients with treatment-refractory major depressive disorder. We were interested in determining the applicability of current recommended doses of aripiprazole as an adjunct to antidepressant therapy in this population.
Treating Depression After Initial Treatment Failure: Directly Comparing Switch and Augmenting Strategies in STAR*D
Objective: Augmenting and switching antidepressant medications are the 2 most common next-step strategies for depressed patients failing initial medication treatment.
High Times for Low-Frequency Stimulation as Endocannabinoids Engage in Hippocampal Long-Term Depression
High Times for Low-Frequency Stimulation as Endocannabinoids Engage in Hippocampal Long-Term Depression
Neuropsychopharmacology 37,
583 (February 2012). doi:10.1038/npp.2011.275
Author: Sachin Patel
Keywords:
NMDA Receptors, mGluR5, and Endocannabinoids are Involved in a Cascade Leading to Hippocampal Long-Term Depression
NMDA Receptors, mGluR5, and Endocannabinoids are Involved in a Cascade Leading to Hippocampal Long-Term Depression
Neuropsychopharmacology 37,
609 (February 2012). doi:10.1038/npp.2011.243
Authors: Yukitoshi Izumi
& Charles F Zorumski
Keywords: Receptor Pharmacology; Cannabinoids; Learning & Memory; Glutamate; Synaptic plasticity; CB1 receptors; Metabotropic glutamate receptors; NMDA receptors; Retrograde messengers
Pilot Randomized Clinical Trial of an SSRI vs Bupropion: Effects on Suicidal Behavior, Ideation, and Mood in Major Depression
Pilot Randomized Clinical Trial of an SSRI vs Bupropion: Effects on Suicidal Behavior, Ideation, and Mood in Major Depression
Neuropsychopharmacology 37,
697 (February 2012). doi:10.1038/npp.2011.247
Authors: Michael F Grunebaum, Steven P Ellis, Naihua Duan, Ainsley K Burke, Maria A Oquendo
& J John Mann
Regional Cortical Thickness and Subcortical Volume Changes Are Associated with Cognitive Impairments in the Drug-Naive Patients with Late-Onset Depression
Regional Cortical Thickness and Subcortical Volume Changes Are Associated with Cognitive Impairments in the Drug-Naive Patients with Late-Onset Depression
Neuropsychopharmacology 37,
838 (February 2012). doi:10.1038/npp.2011.264
Authors: Hyun Kook Lim, Won Sang Jung, Kook Jin Ahn, Wang Youn Won, Changtae Hahn, Seung Yup Lee, InSeong Kim
& Chang Uk Lee
Keywords: aging/geriatrics; Alzheimer's disease; cognition; depression; unipolar/bipolar; cortical thickness
Treatment of depression can increase work productivity
A new study found that employees with depression who receive treatment while still working are significantly more likely to be highly productive than those who do not. This is the first study of its kind to look into a possible correlation between treatment and productivity.