dose

BZD tapering

Hello List,      I see a very distinct outpatient tapering schedule for BZD discontinuation in the CPNP Review Book, but I cannot find the reference for it.  The recommendation is as follows:   Reduce dose ...

Lithium Monitoring Standards

Hello-    My facility is considering changing their monitoring protocol for our inpatient adolescent patients on lithium.  Currently, our protocol is as follows: If admited already on lithium: weekly Li levels while in the ...

SSRI and dextromethorphan interaction

Listmates, Does anyone have any specific experience regarding the significance of the interaction of SSRI agents with higher dose dextromethorphan? Our pain management specialists use dextromethorphan 120mg to 180mg per day on average. The significance ...

Fluphenazine Decanoate

Hi All,   Our facility is having an issue with having to destroy significant amounts of fluphenazine decanoate and I wanted to get input on if and how you might be dealing with it. The way our system works is that patients purchase ...

Lamotrigine and OC's

Hello list,   To clarify, my question (attached below) was prompted by the following from Lexicomp drug interactions:   Contraceptives (Progestins): LamoTRIgine may decrease the serum concentration of Contraceptives (Progestins). ...

Agency is under fire for refusing to supply details of sudden deaths after first dose of multiple sclerosis drug

The European Medicines Agency has been criticised for refusing to supply the French independent drug bulletin, Prescrire, with data on cases of sudden death after the first dose of the multiple...

Max single dose of bupropion SR 12hr

Hello.    I need some help clarifying data regarding max single dose of bupropion SR 12hr.  Most references cite 200mg max single dose for SR formulation which is what I am familiar with.  BCPP exam and review 10-11 notes ...

High Dose Gabapentin for Pain

Good Afternoon,   What is the highest daily dose of gabapentin you all have seen for pain management? Lets assume the patient has normal renal function.   Thank you,   Rachel Grande, Pharm.D. ...

Prediction of Warfarin Dose Reductions in Puerto Rican Patients, Based on Combinatorial CYP2C9 and VKORC1 Genotypes

BACKGROUND: The influence of CYP2C9 and VKORC1 polymorphisms on warfarin dose has been investigated in white, Asian, and African American populations but not in Puerto Rican Hispanic patients.

OBJECTIVE: To test the associations between genotypes, international normalized ratio (INR) measurements, and warfarin dosing and gauge the impact of these polymorphisms on warfarin dose, using a published algorithm.

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