DUE
Adult cases of mitochondrial DNA depletion due to TK2 defect: An expanding spectrum
Objective:
In this study we aim to demonstrate the occurrence of adult forms of TK2 mutations causing progressive mitochondrial myopathy with significant muscle mitochondrial DNA (mtDNA) depletion.
Methods:
Patients' investigations included serum creatine kinase, blood lactate, electromyographic, echocardiographic, and functional respiratory analyses as well as TK2 gene sequencing and TK2 activity measurement. Mitochondrial activities and mtDNA were analyzed in the patients' muscle biopsy.
Children hospitalized at alarming rate due to abuse, U.S. study finds
In one year alone, over 4,500 children in the United States were hospitalized due to child abuse, and 300 of them died of their injuries, researchers report in a new study.
Impact of Inflammation on Brain Volume in Multiple Sclerosis [Original Contribution]
Objective To study changes in brain volume measured monthly in patients treated for relapsing multiple sclerosis due to loss of tissue and the appearance of inflammation.
Reduced striatal activation during reward anticipation due to appetite-provoking cues in chronic schizophrenia: A fMRI study
Publication year: 2011Source: Schizophrenia Research, Available online 28 December 2011O. Grimm, S. Vollstädt-Klein, L. Krebs, M. Zink, M.N. Smolka