epilepsy
New gene discovery unlocks mystery of epilepsy in infants
Researchers have come a step closer to unlocking a mystery that causes epileptic seizures in babies. Benign familial infantile epilepsy has been recognized for some time as infantile seizures, without fever, that run in families but the cause has so far eluded researchers. However, clinical researchers have now discovered a gene.
[2011 Round-Up] Epilepsy: new epidemiological and therapeutic perspectives
In 2011, research in epilepsy has been remarkable because it has pushed the boundaries of data collection, either by expanding the duration of prospective follow-up or by including unmatched numbers of patients in double-blind randomised trials, observational studies, or meta-analyses. As a result, important findings have been reported, particularly in the areas of sudden unexplained death in epilepsy (SUDEP) and teratogenicity.
Comparative efficacy of combination drug therapy in refractory epilepsy
Objective:
We retrospectively examined treatment records of developmentally disabled adults with highly refractory epilepsy to determine whether any combinations of 8 of the most commonly used antiepileptic drugs (AEDs) possessed superior efficacy.
Long-term follow-up of febrile infection–related epilepsy syndrome
Purpose: Febrile infection–related epilepsy syndrome (FIRES) is an increasingly recognized epileptic syndrome that presents with multifocal refractory status epilepticus in previously normal children and evolves into a chronic, refractory, focal epilepsy with associated cognitive and behavioral difficulties. Herein we describe the features of the chronic epilepsy and critically review evidence for the etiology of this syndrome.Methods: Seven patients with FIRES were studied. The duration of follow-up in six survivors was 5–17 years.
Radiosurgery for epilepsy: Clinical experience and potential antiepileptic mechanisms
Stereotactic radiosurgery, well established in the noninvasive treatment of focal lesions that are otherwise difficult to access through open surgery, is an emerging technology in the treatment of focal epileptic lesions. Recent studies suggest that seizures from hypothalamic hamartomas and mesial temporal lobe epilepsy remit at clinically significant rates with radiosurgery, but large variations among different studies have raised questions about appropriate treatment protocols and mechanisms.
Drug-resistant epilepsy.
Ricart JJ | |
Drug-resistant epilepsy.
Sakemi H | |
Drug-resistant epilepsy.
Kobayashi K, Yoshinaga H, Ohtsuka Y | |