epilepsy
[Comment] What does the future hold for patients with epilepsy?
The Standard and New Antiepileptic Drug (SANAD) trial was a multicentre, randomised, open-label comparison of drug treatments for patients with newly diagnosed seizures of presumed partial onset, done in the UK from 2000 to 2006. The original report of arm A of the trial focused on differences in outcomes between five drugs; in this issue of The Lancet Neurology, Bonnett and colleagues report the results of subgroup analyses of data derived from SANAD arm A that focus on patient-related prognostic factors at the time of diagnosis.
Surgical treatment for epilepsy should not be viewed as a last resort, study shows
The majority of people suffering with drug-resistant epilepsy see surgery as a last resort. But researchers now show that early surgical intervention followed by antiepileptic drugs stop seizures, improve quality of life, and help avoid decades of disability.
Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b [Original Contribution]
Context Vaccination with whole-cell pertussis vaccine carries an increased risk of febrile seizures, but whether this risk applies to the acellular pertussis vaccine is not known. In Denmark, acellular pertussis vaccine has been included in the combined diphtheria-tetanus toxoids-acellular pertussis–inactivated poliovirus– Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine since September 2002.
Objective To estimate the risk of febrile seizures and epilepsy after DTaP-IPV-Hib vaccination given at 3, 5, and 12 months.
GLUT1 mutations are a rare cause of familial idiopathic generalized epilepsy
Objective:
The idiopathic generalized epilepsies (IGE) are the most common genetically determined epilepsies. However, the underlying genes are largely unknown. We screened the SLC2A1 gene, encoding the glucose transporter type 1 (GLUT1), for mutations in a group of 95 European patients with familial IGE.
Possible link to hyper-excitability factors in epilepsy, autism and more
A new study is revealing new information about a key protein's role in the development of epilepsy, autism and other neurological disorders. This work could one day lead to new treatments for the conditions.
Identifying Subtle Cortical Gyral Abnormalities as a Predictor of Focal Cortical Dysplasia and a Cure for Epilepsy [Observation]
Objectives To highlight a case series of 3 cases of focal cortical dysplasia that were unrecognized for many years though the patients were seen by various neurologists and received the appropriate neuroimaging studies, and to retrospectively characterize the clinical elements, neuroimaging, electroencephalography, and pathologic findings in these cases.
Design Retrospective descriptive study.
Setting Tertiary urban and suburban neurology and epilepsy outpatient and inpatient clinic settings and hospitals.