families
Prevalence of conduct disorder among families of Mexican migrants in the U.S. examined in new study
The prevalence of conduct disorder appears to have increased substantially across generations of the Mexican-origin population after migration to the United States, however this increase was observed more for nonaggressive than aggressive symptoms of CD, according to a new study.
Archetypal and New Families With Alexander Disease and Novel Mutations in GFAP [Original Contribution]
Objective To describe genetic analyses of the 2 most thoroughly studied, historically seminal multigenerational families with Alexander disease described prior to the identification of GFAP as the related gene, as well as 1 newly discovered family.
Design Clinical histories were obtained and DNA was analyzed from blood, cheek epithelial cells, or fixed paraffin-embedded surgical samples.
Subjects Affected and unaffected adult members of 3 families and affected children were included.
A High-Risk Study of Bipolar Disorder: Childhood Clinical Phenotypes as Precursors of Major Mood Disorders [Original Article]
Context The childhood precursors of adult bipolar disorder (BP) are still a matter of controversy.
Objective To report the lifetime prevalence and early clinical predictors of psychiatric disorders in offspring from families of probands with DSM-IV BP compared with offspring of control subjects.
Design A longitudinal, prospective study of individuals at risk for BP and related disorders. We report initial (cross-sectional and retrospective) diagnostic and clinical characteristics following best-estimate procedures.
Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder
Publication year: 2011Source: Journal of Affective Disorders, In Press, Corrected Proof, Available online 7 September 2011Elizabeth, Hare , Javier, Contreras , Henriette, Raventos , Deborah, Flores , Alvaro, Jerez , ...
A 3p26-3p25 Genetic Linkage Finding for DSM-IV Major Depression in Heavy Smoking Families [Articles]
Objective:
The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking.
Method:
Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pairs design, the authors conducted nonparametric linkage analysis.