model
Medicare Part D’s Impact on Antipsychotic Drug Use and Costs Among Elderly Patients Without Prior Drug Insurance
Abstract: Medicare part D’s implementation improved access to and affordability of prescription drugs for the elderly without prior drug insurance. Effects for specific drugs and drug classes are less well understood. We assessed part D’s impact on antipsychotic medication (APM) utilization and out-of-pocket costs among elderly without prior drug insurance.
Comparison of Natural Language Processing Biosurveillance Methods for Identifying Influenza From Encounter Notes
Background:
An effective national biosurveillance system expedites outbreak recognition and facilitates response coordination at the federal, state, and local levels. The BioSense system, used at the Centers for Disease Control and Prevention, incorporates chief complaints but not data from the whole encounter note into its surveillance algorithms.
Objective:
To evaluate whether biosurveillance by using data from the whole encounter note is superior to that using data from the chief complaint field alone.
Design:
6-year retrospective case–control cohort study.
The Rise and Fall of the Biopsychosocial Model: Reconciling Art and Science in Psychiatry
This is the first book-length historical critique of psychiatry's mainstream ideology, the biopsychosocial (BPS) model.
7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease
7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease
Neuropsychopharmacology 37,
434 (January 2012). doi:10.1038/npp.2011.191
Authors: Latha Devi
& Masuo Ohno
Keywords: Alzheimer's disease; animal models; learning and memory; neurochemistry; TrkB agonist; 7,8-dihydroxyflavone; BDNF; BACE1
Cannabinoids Prevent the Development of Behavioral and Endocrine Alterations in a Rat Model of Intense Stress
Cannabinoids Prevent the Development of Behavioral and Endocrine Alterations in a Rat Model of Intense Stress
Neuropsychopharmacology 37,
456 (January 2012). doi:10.1038/npp.2011.204
Authors: Eti Ganon-Elazar
& Irit Akirav
Acute Severe Animal Model of Anti-Muscle-Specific Kinase Myasthenia: Combined Postsynaptic and Presynaptic Changes [Original Contribution]
Objectives To determine the pathogenesis of anti–muscle-specific kinase (MuSK) myasthenia, a newly described severe form of myasthenia gravis associated with MuSK antibodies characterized by focal muscle weakness and wasting and absence of acetylcholine receptor antibodies, and to determine whether antibodies to MuSK, a crucial protein in the formation of the neuromuscular junction (NMJ) during development, can induce disease in the mature NMJ.
Model to foster new drug development to treat pain and epilepsy developed
Drawing on X-ray crystallography and experimental data, as well as a software suite for predicting and designing protein structures, a researcher has developed an algorithm that predicts what has been impossible to generate in the laboratory: the conformational changes in voltage-gated sodium channels when they are at rest or actively transmitting a signal in muscle and nerve cells.