risk
Pregnancy Outcome After Exposure to Antidepressants and the Role of Maternal Depression: Results From the Norwegian Mother and Child Cohort Study
Abstract: Results of previous studies on the safety of antidepressants during pregnancy have been conflicting. The primary objective of this study was to investigate whether first-trimester exposure to antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs), was associated with increased risk of congenital malformations. The secondary objective was to examine the effects of exposure to antidepressants during pregnancy on birth weight and gestational age.
We included 63,395 women from the Norwegian Mother and Child Cohort Study.
Risk Factors Associated With Metabolic Syndrome in Bipolar and Schizophrenia Subjects Treated With Antipsychotics: The Role of Folate Pharmacogenetics
Abstract: Folate has been implicated in cardiovascular disease with atypical antipsychotic (AAPs) use, and individuals with methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) variants are at greater risk. This study examined the relationship between the MTHFR 677C/T, MTHFR 1298A/C, and COMT Val158Met variants; metabolic syndrome; and lifestyle measures in schizophrenia and bipolar subjects. A total of 237 subjects with bipolar or schizophrenia receiving an antipsychotic for at least 6 months were included in this cross-sectional analysis.
[Comment] Rivaroxaban and recurrent stroke prevention in AF
Atrial fibrillation (AF) is a substantial risk factor for stroke. In the Framingham Study, non-valvular AF was associated with an over five times increased risk of stroke, and rheumatic heart disease with chronic AF was associated with an over 17 times increased risk of stroke. A history of stroke increases stroke risk in patients with AF by almost 12 times. The CHADS2 and CHA2DS2-VASc (an expanded version of CHADS2) clinical scoring systems for stroke risk stratification in AF weight previous stroke with a score of 2, whereas most of the other component factors are weighted with scores of 1.