Symptoms

2010-2011 Psychiatric Pharmacy Review Course - ACPE Credit Only

The Psychiatric Pharmacy Review Course (Review Course) is an excellent course of study and resource for those seeking a review of psychopharmacology and current standards of care. Read more about this session.

Asenapine Versus Olanzapine in People With Persistent Negative Symptoms of Schizophrenia

Abstract: Two randomized, double-blind, 26-week core studies (Eastern [EH] and Western Hemisphere [WH]) tested the hypothesis that asenapine is superior to olanzapine for persistent negative symptoms of schizophrenia; 26-week extension studies assessed the comparative long-term efficacy and safety of these agents. In the core studies, 949 people were randomized to asenapine (n = 241 and 244) or olanzapine (n = 240 and 224); 26-week completion rates with asenapine were 64.7% and 49.6% (olanzapine, 80.4% and 63.8%) in the EH and WH, respectively.

Associations of MAOA-VNTR or 5HTT-LPR alleles with attention-deficit hyperactivity disorder symptoms are moderated by platelet monoamine oxidase B activity

The monoamine systems have been suggested to play a role in the biological basis of attention-deficit hyperactivity disorder (ADHD) symptoms. Thus, polymorphisms, for example, in the monoamine oxidase A (MAOA) and the serotonin transporter (5HTT) genes have been associated with ADHD-like phenotypes. Furthermore, platelet monoamine oxidase B (MAOB) activity has frequently been linked to impulsiveness-related traits. In this study, we have studied ADHD symptoms with regard to the combination of platelet MAOB activity and MAOA-variable number of tandem repeats (VNTR) or 5HTT-LPR genotype.

Only women with symptoms need to have their breast implants removed, says government

The government is playing down the need for women who have breast implants made by a discredited French company to have them removed, in an attempt to lessen continuing fears about their safety.The...

Antidepressant induced EPS

Does anyone by chance have any information regarding comparisons between antidepressants in inducing EPS?   Christopher Ching, PharmD Inpatient Pharmacist Kaiser Permanente Behavioral Health Center 3840 Homestead Rd. Santa Clara, CA 95051 ...

Drug-Induced Movement Disorders

Jack J. Chen, PharmD, FCCP, BCPS, CGP
Associate Professor
Loma Linda University
Loma Linda, CA

This comprehensive review covers approaches for both the recognition and management of drug-induced movement disorders. Pharmacotherapeutic approaches for treating akathisia, dystonia, Parkinsonism and tardive dyskinesia are explored. The importance of early detection via periodic assessment is discussed.

Are Extrapyramidal Symptoms Less Recognized? Case Report of Modern Practitioners’ Unfamiliarity with First Generation Antipsychotics

Tara L. Purvis, PharmD, BCPP
Veteran Affairs Sierra Nevada Healthcare System
Reno, Nevada 89502

The author received no support of any kind in writing this manuscript and has no potential conflicts of interest to disclose.  

The case report was published in Pharmacotherapy February 2011 and presented as a clinical pearl at the CPNP Annual Meeting. In that presentation however. emphasis was placed on the pharmacokinetics of fluphenazine decanoate.

A case is presented where initial suspicion of lithium toxicity was truly drug-induced Parkinsonism and tardive dyskinesia. The mistaken diagnosis underscores the need to improve training for movement disorder assessment.

The Clinician's Role in Assessing for Drug-Induced Movement Disorders: Practices at a Forensic Psychiatric Hospital

O. Greg Deardorff
Clinical Manager
Fulton State Hospital
Fulton, Missouri

Here is one practitioner’s perspective on movement disorder assessment. Read about his experience with assessing movement disorders, particularly tardive dyskinesia.

Comparison of Natural Language Processing Biosurveillance Methods for Identifying Influenza From Encounter Notes

Background:

An effective national biosurveillance system expedites outbreak recognition and facilitates response coordination at the federal, state, and local levels. The BioSense system, used at the Centers for Disease Control and Prevention, incorporates chief complaints but not data from the whole encounter note into its surveillance algorithms.

Objective:

To evaluate whether biosurveillance by using data from the whole encounter note is superior to that using data from the chief complaint field alone.

Design:

6-year retrospective case–control cohort study.

Induction of Psychosis by {Delta}9-Tetrahydrocannabinol Reflects Modulation of Prefrontal and Striatal Function During Attentional Salience Processing [Original Article]

Context  The aberrant processing of salience is thought to be a fundamental factor underlying psychosis. Cannabis can induce acute psychotic symptoms, and its chronic use may increase the risk of schizophrenia. We investigated whether its psychotic effects are mediated through an influence on attentional salience processing.

Objective  To examine the effects of 9-tetrahydrocannabinol (9-THC) and cannabidiol (CBD) on regional brain function during salience processing.

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