QTc Prolongation on initiation of antipsychotic therapy in the very old

Antipsychotic drugs are among the most widely prescribed psychotropic medications for elderly people (1). When using antipsychotic medications, there is a common concern of QT interval prolongation, which may predispose patients to cardiac arrhythmia, Torsade de Pointes and even sudden death. The degree of risk for each patient varies depending on their risk factors, such as underlying pathologies, the antipsychotic medication and dosage used, and concurrent use of other medications. The study will help identify the risk of QTc prolongation in the very old population ( >70 years old), who are initiated on antipsychotic therapy.

Acute Colonic Pseudo-obstruction: A Rare but Dangerous Complication of Clozapine Therapy

Constipation is a well-known and usually benign side effect of antipsychotic therapy; however, clozapine-induced gastrointestinal hypomotility can be associated with significant morbidity. Acute colonic pseudo-obstruction (ACPO), or Ogilvie’s syndrome, is a functional obstruction of the colon leading to decreased intestinal motility due to autonomic dysregulation.

Daclizumab use in patients with pediatric multiple sclerosis.

Gorman MP, Tillema J-M, Ciliax AM, Guttmann CRG, Chitnis T. Daclizumab use in patients with pediatric multiple sclerosis. Arch Neurol. 2012;69(1):78-81. doi: 10.1001/archneurol.2011.581. PubMed PMID: 22232346.

The Impact of Post-Traumatic Stress Disorder on Blood Pressure and Heart Rate in a Veteran Population

Posttraumatic stress disorder (PTSD) is an increasingly recognized anxiety disorder with an estimated prevalence of 6-8% in the general population and 10-30% in the veteran population. Proposed physiological responses associated with PTSD include increased blood pressure (BP) and heart rate (HR). Current literature is limited describing the magnitude of these responses.

L-methylfolate 15 mg as Adjunctive Therapy with Selective Serotonin Reuptake Inhibitors Following Acute Remission for MDD: Results of a 12-Month, Open-Label, Relapse-Prevention Study

Preventing relapse and sustaining remission after acute treatment remain a challenge in the management of major depressive disorder (MDD). The objective of this analysis was to ascertain the efficacy of adjunctive L-methylfolate combined with an SSRI in preventing relapse and sustaining remission in a 12 month open-label treatment phase following a double-blind, placebo-controlled treatment phase.