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Activity Dates: 04/22/2013 - 04/22/2016

This course is closed. Please look for other available products in CPNP University.

Target Audience

If you are a pharmacist, nurse practitioner or other healthcare professional involved in the comprehensive medication management of psychiatric and/or neurological patients, we invite you to participate in this online course.

Session Summary

Approximately 70% of patients with PTSD suffer from disrupted sleep patterns, including nightmares and distressed awakenings. These symptoms are highly disturbing and have a profound negative effect on more than just an individual’s sleep; they likely exacerbate daytime hypervigilance, irritability and anger thresholds, avoidance symptoms, affect physical health and contribute to decreased quality of life. Norepinephrine plays a role in the pathyophysiology of PTSD and it is thought that the increase in the central nervous system responsiveness to norepinephrine contributes to the disruption of normal rapid eye movement sleep, in turn contributing to trauma related nightmares and distressed awakenings. Prazosin, a lipid-soluble alpha-1 adrenoreceptor antagonist, can be used to decrease the responsiveness to norepinephrine in the central nervous system thus returning the patient to a normal sleep pattern. This presentation will review the literature that supports the use of prazosin for the treatment of PTSD-related nightmares. The effects on sleep disturbance of other psychotropic drugs commonly prescribed for PTSD also will be reviewed.

Course Requirements

You will proceed through the following steps to satisfactorily complete this course:

  • Review the full content of the activity and reflect upon its teachings.
  • Complete the post-test at the end of the activity no later than the closing activity date. (login first)
  • Complete the evaluation at the end of the activity. (login first)
  • Receive a passing grade (60%).
  • Provide the necessary details in your profile to ensure correct reporting by CPNP to CPE Monitor. (login first)

This course is provided online at cpnp.org and consists of the speaker audio and slides. A PDF file of the slides is also provided and access is available to participants indefinitely although ACPE credit is available only through the course expiration date.

Participants in this course must complete an examination and achieve a score of 60% or greater. Successful completion of the course also requires the completion of a course evaluation. ACPE statements of credit can be retrieved by participants online at cpnp.org immediately upon successful completion of the course.

Faculty Information and Disclosures

Learning Objectives

  1. Describe prazosin effect on CNS noradrenergic activity.
  2. Review studies of prazosin in PTSD.
  3. Apply knowledge of prazosin effects in PTSD to clinical situations.

Continuing Education Credit and Disclosures

Activity Dates: 04/22/2013 - 04/22/2016
ACPE Contact Hours: 1.0
ACPE Number: 0284-0000-13-009-H01-P (Knowledge)
Nursing Credit Reminder: Note that ACPE credit is accepted for certification renewal.

ACPEThe College of Psychiatric and Neurologic Pharmacists is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This self-study course provides 1.0 contact hours (0.01 CEUs) of knowledge-based continuing education credit from CPNP approved programming. The ACPE universal program number assigned to this course is 0284-000-13-009-L01-P (1.0 contact hours).

ACPE approved contact hours are accepted for ANCC Certification Renewal (see pages 5 and 6): At least 50% (37.5 hours) of your 75 continuing education hours must be formally approved continuing education hours. Formally approved continuing education hours meet one or more of the criteria listed below:

  1. Continuing nursing education (CNE) approved for nursing contact hours by an accredited provider or approver of nursing continuing education
  2. Continuing medical education (CME) approved for CME hours
  3. Sponsored by organizations, agencies, or educational institutions accredited or approved by the American Nurses Credentialing Center (ANCC) or the Accreditation Council for Continuing Medical Education (ACCME) or the Accreditation Council for Pharmacy Education (ACPE) or the Commission on Dietetic Registration

Grant Support

Annual Meeting Grant Provider

Cyberonics