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Activity Dates: 05/01/2012 - 05/01/2015

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Session Summary

Genetic factors can result in variance in drug metabolism enzyme function, which is one major mechanism impacting interindividual variability in therapeutic response and side effects to neuropsychiatric medications. This presentation will discuss the promises of pharmacogenetics in psychiatry with the presentation consisting of three components: 1) Results from a pilot study investigating genetic variants in the drug metabolizing enzymes CYP2D6 and CYP2C19 following antidepressants and antipsychotic treatment, 2) Report on the Pharmacogenetics Research Clinic at our CAMH hospital. Patients with a diagnosis of schizophrenia and mood disorders are being enrolled prospectively and genotyped for CYP2D6 and CYP2C19. 3) Major findings in antipsychotic-induced weight gain (AIWG). Unfortunately, AIWG has become a common side-effect with newer antipsychotics and significantly increases morbidity in patients with schizophrenia.

This presentation will highlight our research in this area. Briefly, 1) Our case-reports suggest a potential clinical benefit of CYP genotyping for specific patients, however further validation of CYP2D6 and CYP2C19 testing in prospective, randomized trials is warranted. 2) Our findings suggest that CYP2D6 and CYP2C19 genotyping provides useful information that help physicians to improve pharmacotherapy for individual patients. 3) Our results tentatively suggest novel associations between functionally relevant gene variants in patients treated with antipsychotic medication for schizophrenia.

In this session, implications for treatment in clinical practice will be discussed as well as potential opportunities in drug discovery and drug development, arising from findings in pharmacogenomic studies.

Course Requirements

You will proceed through the following steps to satisfactorily complete this course:

  • Review the full content of the activity and reflect upon its teachings.
  • Complete the post-test at the end of the activity no later than the closing activity date. (login first)
  • Complete the evaluation at the end of the activity. (login first)
  • Receive a passing grade (60%).
  • Provide the necessary details in your profile to ensure correct reporting by CPNP to CPE Monitor. (login first)

This session was presented live at the 2012 CPNP Annual Meeting. A PDF file of the slides and audio of the speaker’s presentation is provided. ACPE transcripts can be retrieved by participants online at cpnp.org and the credit will be automatically submitted to your account at CPE Monitor shortly after the evaluation is completed.

Faculty Information and Disclosures

Learning Objectives

  1. Illustrate the implications of gene variation.

  2. Summarize the current use of pharmacogenomic testing in clinical practice.

  3. Discuss clinical examples of the benefits of the tests.

  4. Explain how to assess “clinical utility” when practicing individualized medicine.

Continuing Education Credit and Disclosures

Activity Dates: 05/01/2012 - 05/01/2015
ACPE Contact Hours: 1.0
ACPE Number: 0284-9999-12-019-H04-P (Knowledge)
Nursing Credit Reminder: Note that ACPE credit is accepted for certification renewal.

ACPE Credit

The College of Psychiatric and Neurologic Pharmacists is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.


CME Credit

Sponsored by the University of Arizona College of Medicine at the Arizona Health Sciences Center.

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the Joint sponsorship of The University of Arizona College of Medicine at the Arizona Health Sciences Center and the College of Psychiatric and Neurologic Pharmacists. ACCME credit is no longer available for this course.

Nursing Credit

ACPE and ACCME approved contact hours are accepted for ANCC Certification Renewal (as quoted on the ANCC website):  “Other health disciplines' continuing education hours may be used if the content is applicable to your area of certification. ACPE and ACCME are specifically listed as approved credit types.

Grant Support

Annual Meeting Grant Supporter