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Activity Dates: 04/19/2010 - 04/19/2013

This course is closed. Please look for other available products in CPNP University.

Target Audience

If you are a pharmacist, nurse practitioner or other healthcare professional involved in the comprehensive medication management of psychiatric and/or neurological patients, we invite you to participate in this online course.

Session Summary

It is well know that folate is essential for the development and normal function of the central nervous system (CNS).  This is illustrated by the many cases of in-born errors of folate metabolism which lead to profound deleterious effects in the CNS.  The neuropsychiatric complications of folate deficiency from various causes are remarkably similar to those described for vitamin B12 deficiency, but the former is particularly associated with depression and dementia especially in the elderly. Inherited and acquired disorders of folate and B vitamin metabolism are often associated with neurological and psychiatric complications.

Clinical features, which may vary depending on the severity of the defect and age at presentation, may include; lethargy, hypotonia, mental retardation, seizures, encephalopathy, myelopathy, behavioral disturbance, depression and cognitive impairment.  It is clear from clinical studies that the central nervous system is sensitive to disturbances in the metabolism of folate, and that maintaining adequate amounts of folate is essential for normal brain function.  There is substantial evidence that the mechanisms by which folate and B vitamin deficiency causes neurological and psychiatric deficits are multifactoral and various pathways have been implicated including; methylation of DNA and gene expression, key CNS proteins, neurotransmitters, phospholipid metabolism, excitoitoxicity, and oxidative stress. This presentation will focus on the causes and detection of folate and B vitamin deficiency, neurotoxic mechanisms involved and therapeutic options for the treatment of depression and dementia.

Course Requirements

You will proceed through the following steps to satisfactorily complete this course:

  • Review the full content of the activity and reflect upon its teachings.
  • Complete the post-test at the end of the activity no later than the closing activity date. (login first)
  • Complete the evaluation at the end of the activity. (login first)
  • Receive a passing grade (60%).
  • Provide the necessary details in your profile to ensure correct reporting by CPNP to CPE Monitor. (login first)

This course is provided online at cpnp.org and consists of the speaker audio and slides. A PDF file of the slides is also provided and access is available to participants indefinitely although ACPE credit is available only through the course expiration date.

Participants in this course must complete an examination and achieve a score of 60% or greater. Successful completion of the course also requires the completion of a course evaluation. ACPE statements of credit can be retrieved by participants online at cpnp.org immediately upon successful completion of the course.

Faculty Information and Disclosures

Learning Objectives

  1. Describe the metabolism of folate and what factors impact folate activity.
  2. Identify tests that diagnose folate deficiency in humans.
  3. Recognize the biochemical mechanisms of folate deficiency that can lead to depression and dementia.
  4. Develop a pharmacotherapy plan and monitoring parameters for a patient with folate deficiency.

Continuing Education Credit and Disclosures

Activity Dates: 04/19/2010 - 04/19/2013
ACPE Contact Hours: 1.0
ACPE Number: 0284-0000-10-010-H04-P (Knowledge)
Nursing Credit Reminder: Note that ACPE credit is accepted for certification renewal.

ACPEThe College of Psychiatric and Neurologic Pharmacists is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This self-study course provides 1.0 contact hours (0.10 CEUs) of knowledge-based continuing education credit from CPNP approved programming. The ACPE universal program number assigned to this course is 0284-0000-10-010-L04-P (1.0 contact hours).

ACPE approved contact hours are accepted for ANCC Certification Renewal (see pages 5 and 6): At least 50% (37.5 hours) of your 75 continuing education hours must be formally approved continuing education hours. Formally approved continuing education hours meet one or more of the criteria listed below:

  1. Continuing nursing education (CNE) approved for nursing contact hours by an accredited provider or approver of nursing continuing education
  2. Continuing medical education (CME) approved for CME hours
  3. Sponsored by organizations, agencies, or educational institutions accredited or approved by the American Nurses Credentialing Center (ANCC) or the Accreditation Council for Continuing Medical Education (ACCME) or the Accreditation Council for Pharmacy Education (ACPE) or the Commission on Dietetic Registration

Grant Support

This programming was supported in part by grants from Bristol-Myers Squibb, Otsuka America Pharmaceutical, Inc., Lilly USA, LLC, AstraZeneca and Cyberonics.

Annual Meeting Grant Supporter

This activity is supported by an educational grant from Lilly USA, LLC. For further information concerning Lilly grant funding visit www.lillygrantoffice.com.