Psychiatric Pharmacy Essentials: CYP Substrate/Inducer/Inhibitor List: Psychotropic-focus

Changes in cytochrome P450 (CYP) enzyme metabolism are a common cause of drug-drug interactions. Several psychotropic agents are significantly impacted by CYP interactions or cause interactions by inhibiting or inducing CYP metabolism.

  • Is there a list of CYP substrates and interacting medications?1-2
  • Where can I find a database with multiple interaction analyses?3-5
  • How should I interpret drug-drug interaction studies?6

Reviewer 1: Thea Moore, PharmD, BCPP
Reviewer 2: Joseph M. Cusimano, PharmD, BCPP
Reviewer 3: Austin Smith, PharmD, BCPP
2023-2024 AAPP Resident and New Practitioner Committee

References

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed: September 2023. [Weblink]
  2. Pharmacist's Letter: Cytochrome P450 (CYP) Drug Interactions. Updated 2020. [Weblink]
    • Purchase/subscription required
  3. Lexicomp. Updated 2023. [Weblink]
    • Purchase/subscription required
  4. Micromedex. Updated 2023. [Weblink]
    • Purchase/subscription required
  5. Clinical Pharmacology. Updated 2023. [Weblink]
    • Purchase/subscription required
  6. Tornio A, Filppula AM, Niemi M, Backman JT. Clinical studies on drug-drug interactions involving metabolism and transport: methodology, pitfalls, and interpretation. Clin Pharmacol Ther. 2019;105(6):1345-1361. [PubMed]