It is not uncommon for patients to be switched from one antipsychotic to another. Chlorpromazine equivalents help guide clinicians in estimating an approximately equivalent dose when transitioning from one antipsychotic to another.
How should I convert doses between different antipsychotics?1-7
Antipsychotic Dose Equivalents (based on chlorpromazine)
|
Generic |
Brand |
Dose Equivalent |
|
First Generation Antipsychotics |
|
Chlorpromazine |
Thorazine© |
100 mg |
|
Fluphenazine |
Prolixin© |
2 mg |
|
Haloperidol |
Haldol© |
2 mg |
|
Loxapine |
Loxitane© |
10 mg |
|
Perphenazine |
Trilafon© |
8 mg |
|
Pimozide |
Orap© |
2 mg |
|
Prochlorperazine |
Compazine© |
15 mg |
|
Trifluoperazine |
Stelazine© |
2-5 mg |
|
Thioridazine |
Mellaril© |
100 mg |
|
Thiothixene |
Navane© |
4 mg |
|
Second Generation Antipsychotics |
|
Aripiprazole |
Abilify© |
7.5 mg |
|
Asenapine |
Saphris© |
4 mg1 |
|
Brexpiprazole |
Rexulti© |
N/A |
|
Cariprazine |
Vraylar© |
N/A |
|
Clozapine |
Clozaril© |
100 mg |
|
Iloperidone |
Fanapt© |
3-4 mg1 |
|
Lurasidone |
Latuda© |
16 mg1 |
|
Lumateperone |
Caplyta© |
Unknown |
|
Olanzapine |
Zyprexa© |
5 mg |
|
Paliperidone |
Invega© |
2 mg1 |
|
Quetiapine |
Seroquel© |
75 mg |
|
Risperidone |
Risperdal© |
1 mg |
|
Ziprasidone |
Geodon© |
60 mg |
References
- Leucht S, Samara M, Heres S, Patel MX, Woods SW, Davis JM. Dose equivalents for second-generation antipsychotics: the minimum effective dose method. Schizophrenia Bulletin. 2014;40(2):314-26. DOI: 10.1093/schbul/sbu001. PubMed PMID: 24493852; PubMed Central PMCID: PMC3932104.
- Leucht S, Samara M, Heres S, et al. Dose equivalents for second-generation antipsychotic drugs: the classical mean dose method. Schizophr Bull. 2015;41(6):1397-402. [PubMed]
- Patel MX, Arista IA, Taylor M, Barnes TRE. How to compare doses of different antipsychotics: a systematic review of methods. Schizophr Res. 2013;149(1-3):141-8. DOI: 10.1016/j.schres.2013.06.030. PubMed PMID: 23845387.
- Rothe PH, Heres S, Leucht S. Dose equivalents for second generation long-acting injectable antipsychotics: The minimum effective dose method. Schizophrenia Res. 2018;193:23-28. DOI: 10.1016/j.schres.2017.07.033. PubMed PMID: 28735640.
- Taylor D, Paton C, and Kapur S. The Maudsley Prescribing Guidelines in Psychiatry, Wiley-Blackwell; 11th Edition, 2011.
- Schatzberg AF, Cole JO, and DeBattista C. Manual of Clinical Psychopharmacology, American Psychiatric Publishing; 7th Edition, 2010.
- Woods SW. Chlorpromazine Equivalent Doses for the Newer Atypical Antipsychotics. J. Clin. Psychiatry. 2003;64(6):663- 667. DOI: 10.4088/JCP.v64n0607. PubMed PMID: 12823080.
