It is not uncommon that patients may need to be switched from one antipsychotic to another. Chlorpromazine equivalents help guide clinicians in estimating an approximately equivalent dose when transitioning from one antipsychotic to another.
Antipsychotic Dose Equivalents (based on chlorpromazine equivalents)
Generic | Brand | Dose Equivalent |
---|---|---|
First Generation Antipsychotics | ||
Chlorpromazine | Thorazine© | 100 mg |
Fluphenazine | Prolixin© | 2 mg |
Haloperidol | Haldol© | 2 mg |
Loxapine | Loxitane© | 10 mg |
Perphenazine | Trilafon© | 8 mg |
Pimozide | Orap© | 2 mg |
Prochlorperazine | Compazine© | 15 mg |
Trifluoperazine | Stelazine© | 2-5 mg |
Thioridazine | Mellaril© | 100 mg |
Thiothixene | Navane© | 4 mg |
Second Generation Antipsychotics | ||
Aripiprazole | Abilify© | 7.5 mg |
Asenapine | Saphris© | 4 mg1 |
Brexpiprazole | Rexulti© | N/A |
Cariprazine | Vraylar© | N/A |
Clozapine | Clozaril© | 100 mg |
Iloperidone | Fanapt© | 3-4 mg1 |
Lurasidone | Latuda© | 16 mg1 |
Olanzapine | Zyprexa© | 5 mg |
Paliperidone | Invega© | 2 mg1 |
Quetiapine | Seroquel© | 75 mg |
Risperidone | Risperdal© | 1 mg |
Ziprasidone | Geodon© | 60 mg |
Long acting injectable antipsychotic IM Equivalents
Based on: Rothe PH, Heres S, Leucht S. Dose equivalents for second generation long-acting injectable antipsychotics: The minimum effective dose method. Schizophr Res. 2018;193:23-8.
Antipsychotic Long Acting Injection | Minimum Effective Dose |
---|---|
Aripiprazole lauroxil (Aristada) | 441mg (300mg of aripiprazole) every 4 weeks |
Aripiprazole microspheres (Abilify Maintena) | 400mg every 4 weeks |
Haloperidol decanoate (Haldol Decanoate) | 50mg every 4 weeks |
Olanzapine pamoate (Zyprexa Relprevv) | 210mg every 2 weeks |
Paliperidone palmitate (Invega Sustenna) | 25mg every 4 weeks |
Risperidone microspheres (Risperdal Consta) | 25mg every 2 weeks |
Risperidone suspension (Perseris) | 90mg every 4 weeks |
Minimum effective dose defined as the lowest fixed dose from at least one double blind randomized control trial which demonstrated consistent superior efficacy over placebo.4