For pediatric patients with anxiety or depressive disorders, pharmacotherapy is often combined with cognitive behavioral therapy.

Essential Questions and References

What is the evidence for combination of pharmacotherapy and cognitive behavioral therapy for managing obsessive compulsive disorder in pediatric patients?

POTS II (Pediatric OCD Treatment Study II)

  1. Franklin M, Sapyta J, Freeman J, et al. Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: the Pediatric OCD Treatment Study II (POTS II) randomized controlled trial. JAMA. 2011;306(11):1224-32. [PubMed]

What is the evidence for combination of pharmacotherapy and cognitive behavioral therapy for managing depression in pediatric patients?

TADS (Treatment for Adolescents with Depression Study)

  1. March J, Silva S, Petrycki S, et al. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study (TADS) randomized controlled trial. JAMA. 2004;292(7):807-20. [PubMed]

TORDIA (Treatment of SSRI-Resistant Depression in Adolescents)

  1. Brent D, Emslie G, Clarke G, et al. Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial. JAMA. 2008;299(8):901-13. [PubMed]