Numerous pharmacologic regimens have been trialed for management of substance abuse, often with concomitant behavioral interventions.

Essential Questions and References

What is the evidence for combination of pharmacotherapy and behavioral intervention for managing symptoms of alcohol dependence?

  1. Anton RF, O’Malley SS, Ciraulo DA, et al. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA. 2006;295(17):2003-17. [PubMed]

What treatment options are available for the treatment of opioid dependence?

  1. Pinto H, Maskrey V, Swift L, Rumball D, Wagle A, Holland R. The SUMMIT trial: a field comparison of buprenorphine versus methadone maintenance treatment. J Subst Abuse Treat. 2010;39(4):340-352. [PubMed]