Helpful Insights forPatients and Caregivers

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What is treatment-resistant depression?

Treatment-resistant depression means different things to different people. Most often, it means a person has tried two or more antidepressants for several weeks each and still has depressive symptoms.1 Some common antidepressants are: Zoloft®, Celexa®, Lexapro®, Prozac®, Cymbalta®, Effexor®.

References

  1. McIntyre RS, Filteau M-J, Martin L, Patry S, Carvalho A, Cha DS, et al. Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach. J Affect Disord. 2014;156:1-7. DOI: 10.1016/j.jad.2013.10.043. PubMed PMID: 24314926.
  2. nami.org [Internet]. National Alliance on Mental Illness; c2017 [cited 2019 Sept 11]. Available from https://www.nami.org.
  3. Thase ME, Friedman ES, Biggs MM, Wisniewski SR, Trivedi MH, Luther JF, et al. Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D report. AJP. 2007;164(5):739-52. DOI: 10.1176/ajp.2007.164.5.739. PubMed PMID: 17475733.
  4. Sarris, J., O’Neil, A., Coulson, C.E., Schweitzer, I., and Berk, M. Lifestyle medicine for depression. BMC Psychiatry. 2014;14(107). doi: 10.1186/1471-244X-14-107.
  5. O’Conor, R., Benavente, J.Y., Kwasny, M.J., Eldeirawi, K., Hasnain-Wynia, R., Federman, A.D., et al. Daily Routine: Associations with Health Status and Urgent Health Care Utilization Among Older Adults. The Gerontologist. 2018;XX(X):1-9. doi: 10.1093/geront/gny117.
  6. Aiken C. New answers for treatment-resistant depression. Psychiatric Times. Published August 16, 2020. Accessed March 10, 2021. Available from: https://www.psychiatrictimes.com/view/new-answers-treatment-resistant-depression