Helpful Insights forPatients and Caregivers

Download PDF

What is treatment-resistant depression?

Treatment-resistant depression means different things to different people. Most often, it means a person has tried two or more antidepressants for several weeks each and still has depressive symptoms.1 Some common antidepressants are: Zoloft®, Celexa®, Lexapro®, Prozac®, Cymbalta®, Effexor®.

References

  1. McIntyre RS, Filteau M-J, Martin L, Patry S, Carvalho A, Cha DS, et al. Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach. J Affect Disord. 2014;156:1-7. DOI: 10.1016/j.jad.2013.10.043. PubMed PMID: 24314926.
  2. nami.org [Internet]. National Alliance on Mental Illness; c2017 [cited 2019 Sept 11]. Available from https://www.nami.org.
  3. Thase ME, Friedman ES, Biggs MM, Wisniewski SR, Trivedi MH, Luther JF, et al. Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D report. AJP. 2007;164(5):739-52. DOI: 10.1176/ajp.2007.164.5.739. PubMed PMID: 17475733.
  4. Sarris J, O'Neil A, Coulson CE, Schweitzer I, Berk M. Lifestyle medicine for depression. Bmc Psychiatry. 2014;14:107. DOI: 10.1186/1471-244X-14-107. PubMed PMID: 24721040; PubMed Central PMCID: PMC3998225.
  5. O'Conor R, Benavente JY, Kwasny MJ, Eldeirawi K, Hasnain-Wynia R, Federman AD, et al. Daily Routine: Associations With Health Status and Urgent Health Care Utilization Among Older Adults. Gerontologist. 2019;59(5):947-955. DOI: 10.1093/geront/gny117. PubMed PMID: 30247549.