Contrasting effects of increased and decreased dopamine transmission on latent inhibition in ovariectomized rats and their modulation by 17beta-estradiol: an animal model of menopausal psychosis?

Arad M, Weiner I. Contrasting effects of increased and decreased dopamine transmission on latent inhibition in ovariectomized rats and their modulation by 17beta-estradiol: an animal model of menopausal psychosis?. Neuropsychopharmacology. 2010;35(7):1570-82. DOI: 10.1038/npp.2010.28. PubMed PMID: 20237462; PubMed Central PMCID: PMC3055453.

Use of metformin to control clozapine-associated weight gain in an adolescent with schizoaffective disorder.

Weaver LA, De León DD, Borgmann-Winter K, Coffey BJ. Use of metformin to control clozapine-associated weight gain in an adolescent with schizoaffective disorder. J Child Adolesc Psychopharmacol. 2010;20(2):153-7. DOI: 10.1089/cap.2010.2022. PubMed PMID: 20415612.

Impact of tobacco smoking cessation on stable clozapine or olanzapine treatment.

Lowe EJ, Ackman ML. Impact of tobacco smoking cessation on stable clozapine or olanzapine treatment. Ann Pharmacother. 2010;44(4):727-32. DOI: 10.1345/aph.1M398. PubMed PMID: 20233914.

Comparison of the efficacy and impact on cognition of glycopyrrolate and biperiden for clozapine-induced sialorrhea in schizophrenic patients: a randomized, double-blind, crossover study.

Liang C-S, Ho P-S, Shen L-J, Lee W-K, Yang F-W, Chiang K-T. Comparison of the efficacy and impact on cognition of glycopyrrolate and biperiden for clozapine-induced sialorrhea in schizophrenic patients: a randomized, double-blind, crossover study. Schizophrenia Res. 2010;119(1-3):138-44. DOI: 10.1016/j.schres.2010.02.1060. PubMed PMID: 20299191.

A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia.

Barakauskas VE, Beasley CL, Barr AM, Ypsilanti AR, Li H-Y, Thornton AE, et al. A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia. Neuropsychopharmacology. 2010;35(5):1226-38. DOI: 10.1038/npp.2009.228. PubMed PMID: 20072114; PubMed Central PMCID: PMC3055413.

D-Serine and a glycine transporter-1 inhibitor enhance social memory in rats.

Shimazaki T, Kaku A, Chaki S. D-Serine and a glycine transporter-1 inhibitor enhance social memory in rats. Psychopharmacology. 2010;209(3):263-70. DOI: 10.1007/s00213-010-1794-y. PubMed PMID: 20198471.

Effectiveness of clozapine for the treatment of aggression in an adolescent with autistic disorder.

Lambrey S, Falissard B, Martin-Barrero M, Bonnefoy C, Quilici G, Rosier A, et al. Effectiveness of clozapine for the treatment of aggression in an adolescent with autistic disorder. J Child Adolesc Psychopharmacol. 2010;20(1):79-80. DOI: 10.1089/cap.2009.0057. PubMed PMID: 20166802.

Annual Meeting Point-Counterpoint Keynote Speakers Begin the Debate on Efficacy vs. Tolerability: Which Trumps?

CPNP will once again feature the popular point-counterpoint debate session at the 2010 Annual Meeting, this year on the topic of Antipsychotic Efficacy versus Adverse Effects. Drs. Peter Buckley (Professor and Chairman, Department of Psychiatry and Behavioral Health at the Medical College of Georgia) and Henry Nasrallah (Professor of Psychiatry, Neurology and Neuroscience and Director of the Schizophrenia Research Program at the University of Cincinnati College of Medicine) will provide a thorough discussion of the relative efficacy and tolerability profiles of the typical antipsychotic versus the atypical antipsychotics, in the context of individualizing treatments for patients with schizophrenia. The format of the session will be designed to provide a review of the available literature followed by a debate format between these two well-known clinical researchers. Read on to gain a small preview into this topic and the session to be featured at the CPNP Annual Meeting. Read more about this session.

Effect of omeprazole on clozapine pharmacokinetics in patients with chronic schizophrenia

Clozapine is a highly effective atypical antipsychotic. It is hepatically transformed to N-desmethylclozapine (NDMC, norclozapine, primary metabolite) and clozapine-N-oxide (CNO). Omeprazole is a commonly utilized proton pump inhibitor that is an inducer and inhibitor of the hepatic CYP450 1A2 isoform, as well as an inhibitor of CYP3A4, 2C19, 2C9 and 2D6. There are several case reports of omeprazole interacting with clozapine, however the observed change in clozapine concentration varies from report to report and there is much heterogeneity between baseline characteristics of the patients in the reported cases.

A Case Study: The Comparative Effects of Clozapine, Olanzapine, Valproic Acid, and Lithium on the WBC and ANC in an Intellectually Disabled Individual.

Low Absolute Neutrophil Count (ANC), can lead to Agranulocytosis. Clozapine is well known to cause low ANC. Recent research on other psychiatric medications has identified drug induced neutropenia.