NMDA receptors and memory encoding.

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Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.

Papouin T, Ladépêche L, Ruel J, Sacchi S, Labasque M, Hanini M, et al.. Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. Cell. 2012;150(3):633-46. DOI: 10.1016/j.cell.2012.06.029. PubMed PMID: 22863013.

D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices.

Shleper M, Kartvelishvily E, Wolosker H. D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices. J Neurosci. 2005;25(41):9413-7. DOI: 10.1523/JNEUROSCI.3190-05.2005. PubMed PMID: 16221850.

Glycine binding primes NMDA receptor internalization.

Nong Y, Huang Y-Q, Ju W, Kalia LV, Ahmadian G, Wang YT, et al. Glycine binding primes NMDA receptor internalization. Nature. 2003;422(6929):302-7. DOI: 10.1038/nature01497. PubMed PMID: 12646920.

Nicotine exposure in vivo induces long-lasting enhancement of NMDA receptor-mediated currents in the hippocampus.

Yamazaki Y, Jia Y, Niu R, Sumikawa K. Nicotine exposure in vivo induces long-lasting enhancement of NMDA receptor-mediated currents in the hippocampus. Eur J Neurosci. 2006;23(7):1819-28. DOI: 10.1111/j.1460-9568.2006.04714.x. PubMed PMID: 16623839.

Reduction of brain kynurenic acid improves cognitive function.

Kozak R, Campbell BM, Strick CA, Horner W, Hoffmann WE, Kiss T, et al. Reduction of brain kynurenic acid improves cognitive function. J Neurosci. 2014;34(32):10592-602. DOI: 10.1523/JNEUROSCI.1107-14.2014. PubMed PMID: 25100593.

The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus.

Burgdorf J, Zhang X-L, Weiss C, Gross A, Boikess SR, Kroes RA, et al. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience. 2015;308:202-11. DOI: 10.1016/j.neuroscience.2015.09.004. PubMed PMID: 26343295.

The NR1 N-methyl-D-aspartate subunit and brain-derived neurotrophic factor in temporal lobe epilepsy hippocampus: a comparison of patients with and without coexisting psychiatric symptoms.

Toro CT, Hallak JE, Dunham JS, Leite JP, Sakamoto AC, Guarnieri R, et al. The NR1 N-methyl-D-aspartate subunit and brain-derived neurotrophic factor in temporal lobe epilepsy hippocampus: a comparison of patients with and without coexisting psychiatric symptoms. Epilepsia. 2007;48(12):2352-6. DOI: 10.1111/j.1528-1167.2007.01194.x. PubMed PMID: 17919302.

BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis.

Harrisberger F, Smieskova R, Schmidt A, Lenz C, Walter A, Wittfeld K, et al. BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2015;55:107-18. DOI: 10.1016/j.neubiorev.2015.04.017. PubMed PMID: 25956254.

Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls.

Zhang XY, Chen DC, Xiu MH, Haile CN, Luo X, Xu K, et al. Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls. Hum Genet. 2012;131(7):1187-95. DOI: 10.1007/s00439-012-1150-x. PubMed PMID: 22362486; PubMed Central PMCID: PMC3671849.