This collection of essentials provides resources, references, and clinical pearls for practitioners beginning to practice in psychiatry. Citations of landmark trials are provided. Additional resources are based on questions psychiatric pharmacy specialists frequently receive and aims to provide evidence-based support of recommendations. This also contains references to support monitoring and management of adverse effects and drug interactions of psychotropic medications. The information presented is meant to be a guide for new practitioners and to be used for information purposes only. The CPNP Residency and New Practitioner committee does not endorse the answers provided nor testify that they represent the best available evidence.